慢性乙型肝炎防治指南2010年更新版 9

附3. 慢性乙型肝炎治疗一般流程图（图略）

参考文献

[1] 中华医学会肝病学分会、感染病学分会. 慢性乙型肝炎防治指南. 中华肝脏病杂志, 2005,13(12):881-891.
[2] Seeger C, Mason WS. Hepatitis B virus biology. Microbiol Mol Biol Rev, 2000,64(1):51-68.
[3] Scaglioni PP, Melegari M, Wands JR. Biologic properties of hepatitis B viral genomes with mutations in the precore promoter and precore open reading frame. Virology, 1997,233(2):374-81.
[4] Tran TT, Trinh TN, Abe K. New complex recombinant genotype of hepatitis B virus identified in Vietnam. J Virol, 2008,82(11):5657-63.
[5] Olinger CM, Jutavijittum P, Hubschen JM, et al. Possible new hepatitis B virus genotype, southeast Asia. Emerg Infect Dis, 2008,14(11):1777-80.
[6] Chu CJ, Hussain M, Lok AS. Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C. Gastroenterology, 2002,122(7):1756-62.
[7] Chu CM, Liaw YF. Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: a longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at baseline. J Hepatol, 2005,43(3):411-7.
[8] Yu MW, Yeh SH, Chen PJ, et al. Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men. J Natl Cancer Inst, 2005,97(4):265-72.
[9] Zhang HW, Yin JH, Li YT, et al. Risk factors for acute hepatitis B and its progression to chronic hepatitis in Shanghai, China. Gut, 2008,57(12):1713-20.
[10] Hou J, Schilling R, Janssen HL, et al. Genetic characteristics of hepatitis B virus genotypes as a factor for interferon-induced HBeAg clearance. J Med Virol, 2007,79(8):1055-63.
[11] Jardi R, Rodriguez-Frias F, Schaper M, et al. Analysis of hepatitis B genotype changes in chronic hepatitis B infection: Influence of antiviral therapy. J Hepatol, 2008,49(5):695-701.
[12] Liu CJ, Kao JH. Genetic variability of hepatitis B virus and response to antiviral therapy. Antivir Ther, 2008,13(5):613-24.
[13] Ganem D, Prince AM. Hepatitis B virus infection--natural history and clinical consequences. N Engl J Med, 2004,350(11):1118-29.
[14] Organization., W. H. Hepatitis B. World Health Organization Fact Sheet 204 dex. (Revised October 2000). WHO Web site .http://www.who.int/mediacentre/ factsheets/fs204/en/ in html .
[15] Liang X, Bi S, Yang W, et al. Epidemiological serosurvey of hepatitis B in China--declining HBV prevalence due  to hepatitis B vaccination. Vaccine, 2009,27(47):6550-7.
[16] Liang X, Bi S, Yang W, et al. Evaluation of the impact of hepatitis B vaccination among children born during 1992-2005 in China. J Infect Dis, 2009,200(1):39-47.
[17] Lu FM, Zhuang H. Management of hepatitis B in China. Chin Med J (Engl), 2009,122(1):3-4.
[18] Mast EE, Margolis HS, Fiore AE, et al. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) part 1: immunization of infants, children, and adolescents. MMWR Recomm Rep, 2005,54(RR-16):1-31.
[19] Hepatitis B.http://www.who.int/csr/disease/hepatitis/ whocdscsrlyo2002 2./ou/ .
[20] Lai CL, Ratziu V, Yuen MF, et al. Viral hepatitis B. Lancet, 2003,362(9401):2089-94.
[21] Liaw YF. Natural history of chronic hepatitis B virus infection and long-term outcome under treatment. Liver Int, 2009,29 Suppl 1:100-7.
[22] Hui CK, Leung N, Yuen ST, et al. Natural history and disease progression in Chinese chronic hepatitis B patients in immune-tolerant phase. Hepatology, 2007,46(2):395-401.
[23] McMahon BJ. The natural history of chronic hepatitis B virus infection. Hepatology, 2009,49(5 Suppl):S45-55.
[24] Liaw YF. Hepatitis flares and hepatitis B e antigen seroconversion: implication in anti-hepatitis B virus therapy. J Gastroenterol Hepatol, 2003,18(3):246-52.
[25] Chu CM, Hung SJ, Lin J, et al. Natural history of hepatitis B e antigen to antibody seroconversion in patients with normal serum aminotransferase levels. Am J Med, 2004,116(12):829-34.
[26] Fattovich G, Brollo L, Alberti A, et al. Long-term follow-up of anti-HBe-positive chronic active hepatitis B. Hepatology, 1988,8(6):1651-4.
[27] Brunetto MR, Oliveri F, Rocca G, et al. Natural course and response to interferon of chronic hepatitis B accompanied by antibody to hepatitis B e antigen. Hepatology, 1989,10(2):198-202.
[28] Di MV, Lo IO, Camma C, et al. The long-term course of chronic hepatitis B. Hepatology, 1999,30(1):257-64.
[29] Chu CM, Liaw YF. Hepatitis B virus-related cirrhosis: natural history and treatment. Semin Liver Dis, 2006,26(2):142-52.
[30] Chen YC, Chu CM, Yeh CT, et al. Natural course following the onset of cirrhosis in patients with chronic hepatitis B: a long-term follow-up study. Hepatol Int, 2007,1(1):267-73.
[31] Hsu YS, Chien RN, Yeh CT, et al. Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B. Hepatology, 2002,35(6):1522-7.
[32] Chou YC, Yu MW, Wu CF, et al. Temporal relationship between hepatitis B virus enhancer II/basal core promoter sequence variation and risk of hepatocellular carcinoma. Gut, 2008,57(1):91-7.
[33] Chen CJ, Yang HI, Su J, et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA, 2006,295(1):65-73.
[34] Yang HI, Lu SN, Liaw YF, et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. N Engl J Med, 2002,347(3):168-74.
[35] Iloeje UH, Yang HI, Su J, et al. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology, 2006,130(3):678-86.
[36] Tai DI, Chen CH, Chang TT, et al. Eight-year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: role of viral infection. J Gastroenterol Hepatol, 2002,17(6):682-9.
[37] 中国疾病预防控制中心. 乙型肝炎疫苗儿童计划免疫技术管理规程 (试行). 2002.
[38] 夏国良, 龚健, 王继杰, 等. 重组乙型肝炎疫苗阻断乙型肝炎病毒母婴传播方案的保护效果评价. 中华流行病学杂志, 2003,24(5):362-365.
[39] 邢玉兰; 龚晓红; 周绍莲,等. 阻断围产期母婴传播最佳免疫方案的研究[J]. 中华实验和临床病毒学杂志, 1990, 4:-488 .
[40] CDC. Hepatitis B. http://www.cdc.gov/ncidod/diseases/hepatitis/b/ education/hbv_and_you_chi.pdf WHO .
[41] Hepatitis B and breastfeeding.  http://www.who.int /child-adolescent-health/New_Publications /NUTRITION/updt-22.htm  (online on Oct 23, 2005)[J] .
[42] Zanetti AR, Mariano A, Romano L, et al. Long-term immunogenicity of hepatitis B vaccination and policy for booster: an Italian multicentre study. Lancet, 2005,366(9494):1379-84.
[43] John TJ, Cooksley G. Hepatitis B vaccine boosters: is there a clinical need in high endemicity populations. J Gastroenterol Hepatol, 2005,20(1):5-10.
[44] Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Postexposure Prophylaxis. MMWR Recomm Rep, 2001,50(RR-11):1-52.
[45] 病毒性肝炎防治方案. 病毒性肝炎防治方案. 中华肝脏病杂志, 2000,8(6):324.
[46] Pawlotsky JM, Dusheiko G, Hatzakis A, et al. Virologic monitoring of hepatitis B virus therapy in clinical trials and practice: recommendations for a standardized approach. Gastroenterology, 2008,134(2):405-15.
[47] Shaheen AA, Wan AF, Myers RP. FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy. Am J Gastroenterol, 2007,102(11):2589-600.
[48] Scott DR, Levy MT. Liver transient elastography (Fibroscan): a place in the management algorithms of chronic viral hepatitis. Antivir Ther, 2010,15(1):1-11.
[49] Lin SM, Yu ML, Lee CM, et al. Interferon therapy in HBeAg positive chronic hepatitis reduces progression to cirrhosis and hepatocellular carcinoma. J Hepatol, 2007,46(1):45-52.
[50] Piratvisuth T, Lau G, Chao YC, et al. Sustained response to peginterferon alfa-2a (40 kD) with or without lamivudine in Asian patients with HBeAg-positive and HBeAg-negative chronic hepatitis B. Hepatol Int, 2008,2(1):102-10.
[51] Chan HL, Leung NW, Hui AY, et al. A randomized, controlled trial of combination therapy for chronic hepatitis B: comparing pegylated interferon-alpha2b and lamivudine with lamivudine alone. Ann Intern Med, 2005,142(4):240-50.
[52] Flink HJ, van ZM, Hansen BE, et al. Treatment with Peg-interferon alpha-2b for HBeAg-positive chronic hepatitis B: HBsAg loss is associated with HBV genotype. Am J Gastroenterol, 2006,101(2):297-303.
[53] Buster EH, Flink HJ, Cakaloglu Y, et al. Sustained HBeAg and HBsAg loss after long-term follow-up of HBeAg-positive patients treated with peginterferon alpha-2b. Gastroenterology, 2008,135(2):459-67.
[54] Marcellin P, Bonino F, Lau GK, et al. Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon alpha-2a. Gastroenterology, 2009,136(7):2169-2179.e1-4.
[55] Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology, 2007,45(2):507-39.
[56] Keeffe EB, Dieterich DT, Han SH, et al. A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: an update. Clin Gastroenterol Hepatol, 2006,4(8):936-62.
[57] Fried MW, Piratvisuth T, Lau GK, et al. HBeAg and hepatitis B virus DNA as outcome predictors during therapy with peginterferon alfa-2a for HBeAg-positive chronic hepatitis B. Hepatology, 2008,47(2):428-34.
[58] Moucari R, Mackiewicz V, Lada O, et al. Early serum HBsAg drop: a strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients. Hepatology, 2009,49(4):1151-7.
[59] Brunetto MR, Moriconi F, Bonino F, et al. Hepatitis B virus surface antigen levels: a guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B. Hepatology, 2009,49(4):1141-50.
[60] Lok AS, Lai CL, Leung N, et al. Long-term safety of lamivudine treatment in patients with chronic hepatitis B. Gastroenterology, 2003,125(6):1714-22.
[61] Lai CL, Chien RN, Leung NW, et al. A one-year trial of lamivudine for chronic hepatitis B. Asia Hepatitis Lamivudine Study Group. N Engl J Med, 1998,339(2):61-8.
[62] Liaw YF, Leung NW, Chang TT, et al. Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia Hepatitis Lamivudine Study Group. Gastroenterology, 2000,119(1):172-80.
[63] Dienstag JL, Schiff ER, Wright TL, et al. Lamivudine as initial treatment for chronic hepatitis B in the United States. N Engl J Med, 1999,341(17):1256-63.
[64] Chien RN, Liaw YF, Atkins M. Pretherapy alanine transaminase level as a determinant for hepatitis B e antigen seroconversion during lamivudine therapy in patients with chronic hepatitis B. Asian Hepatitis Lamivudine Trial Group. Hepatology, 1999,30(3):770-4.
[65] Dienstag JL, Goldin RD, Heathcote EJ, et al. Histological outcome during long-term lamivudine therapy. Gastroenterology, 2003,124(1):105-17.
[66] Liaw YF, Sung JJ, Chow WC, et al. Lamivudine for patients with chronic hepatitis B and advanced liver disease. N Engl J Med, 2004,351(15):1521-31.
[67] Villeneuve JP, Condreay LD, Willems B, et al. Lamivudine treatment for decompensated cirrhosis resulting from chronic hepatitis B. Hepatology, 2000,31(1):207-10.
[68] Perrillo RP, Wright T, Rakela J, et al. A multicenter United States-Canadian trial to assess lamivudine monotherapy before and after liver transplantation for chronic hepatitis B. Hepatology, 2001,33(2):424-32.
[69] Hann HW, Fontana RJ, Wright T, et al. A United States compassionate use study of lamivudine treatment in nontransplantation candidates with decompensated hepatitis B virus-related cirrhosis. Liver Transpl, 2003,9(1):49-56.
[70] Jonas MM, Mizerski J, Badia IB, et al. Clinical trial of lamivudine in children with chronic hepatitis B. N Engl J Med, 2002,346(22):1706-13.
[71] Figlerowicz M, Kowala-Piaskowska A, Filipowicz M, et al. Efficacy of lamivudine in the treatment of children with chronic hepatitis B. Hepatol Res, 2005,31(4):217-22.
[72] 姚光弼, 崔振宇, 姚集鲁, 等. 国产拉米夫定治疗2200例慢性乙型肝炎的Ⅳ期临床试验. 中华肝脏病杂志, 2003,11(2):103-108.
[73] 姚光弼, 王宝恩, 崔振宇, 等. 拉米夫定治疗慢性乙型肝炎三年疗效观察. 中华内科杂志, 2003,42(6):382-387.
[74] 曾民德, 茅益民, 姚光弼, 等. 阿德福韦酯治疗HBeAg阳性的中国慢性乙型病毒性肝炎患者52周的多中心临床研究. 中华传染病杂志, 2005,23(6):387-394.
[75] Marcellin P, Chang TT, Lim SG, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N Engl J Med, 2003,348(9):808-16.
[76] Marcellin P, Chang TT, Lim SG, et al. Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. Hepatology, 2008,48(3):750-8.
[77] Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, et al. Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years. Gastroenterology, 2006,131(6):1743-51.
[78] Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, et al. Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B. N Engl J Med, 2005,352(26):2673-81.
[79] Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, et al. Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B. N Engl J Med, 2003,348(9):800-7.
[80] Lampertico P, Vigano M, Manenti E, et al. Low resistance to adefovir combined with lamivudine: a 3-year study of 145 lamivudine-resistant hepatitis B patients. Gastroenterology, 2007,133(5):1445-51.
[81] Rapti I, Dimou E, Mitsoula P, et al. Adding-on versus switching-to adefovir therapy in lamivudine-resistant HBeAg-negative chronic hepatitis B. Hepatology, 2007,45(2):307-13.
[82] Lampertico P, Vigano M, Manenti E, et al. Adefovir rapidly suppresses hepatitis B in HBeAg-negative patients developing genotypic resistance to lamivudine. Hepatology, 2005,42(6):1414-9.
[83] Peters MG, Hann HH, Martin P, et al. Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B. Gastroenterology, 2004,126(1):91-101.
[84] Perrillo R, Hann HW, Mutimer D, et al. Adefovir dipivoxil added to ongoing lamivudine in chronic hepatitis B with YMDD mutant hepatitis B virus. Gastroenterology, 2004,126(1):81-90.
[85] Marzano A, Lampertico P, Mazzaferro V, et al. Prophylaxis of hepatitis B virus recurrence after liver transplantation in carriers of lamivudine-resistant mutants. Liver Transpl, 2005,11(5):532-8.
[86] 张雅敏, 朱志军, 郑虹, 等. 阿德福韦在预防肝移植后乙肝复发中的作用. 中华肝胆外科杂志, 2006,12(5):313-315.
[87] Chang TT, Gish RG, de Man R, et al. A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N Engl J Med, 2006,354(10):1001-10.
[88] Lai CL, Shouval D, Lok AS, et al. Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B. N Engl J Med, 2006,354(10):1011-20.
[89] Gish RG, Lok AS, Chang TT, et al. Entecavir therapy for up to 96 weeks in patients with HBeAg-positive chronic hepatitis B. Gastroenterology, 2007,133(5):1437-44.
[90] Yokosuka O, Takaguchi K, Fujioka S, et al. Long-term use of entecavir in nucleoside-naive Japanese patients with chronic hepatitis B infection. J Hepatol, 2010,52(6):791-9.
[91] Sherman M, Yurdaydin C, Sollano J, et al. Entecavir for treatment of lamivudine-refractory, HBeAg-positive chronic hepatitis B. Gastroenterology, 2006,130(7):2039-49.
[92] 姚光弼, 计焱焱, 任红, 等. 恩替卡韦治疗拉米夫定失效慢性乙型肝炎一年的疗效. 中华传染病杂志, 2006,24(6):385-389.
[93] 姚光弼, 朱玫, 王宇明, 等. 恩替卡韦与拉米夫定治疗慢性乙型肝炎随机、双盲、双模拟对照研究. 中华内科杂志, 2006,45(11):891-895.
[94] Liaw YF, Gane E, Leung N, et al. 2-Year GLOBE trial results: telbivudine Is superior to lamivudine in patients with chronic hepatitis B. Gastroenterology, 2009,136(2):486-95.
[95] Lai CL, Gane E, Liaw YF, et al. Telbivudine versus lamivudine in patients with chronic hepatitis B. N Engl J Med, 2007,357(25):2576-88.
[96] Hou J, Yin YK, Xu D, et al. Telbivudine versus lamivudine in Chinese patients with chronic hepatitis B: Results at 1 year of a randomized, double-blind trial. Hepatology, 2008,47(2):447-54.
[97] Zeuzem S, Gane E, Liaw YF, et al. Baseline characteristics and early on-treatment response predict the outcomes of 2 years of telbivudine treatment of chronic hepatitis B. J Hepatol, 2009,51(1):11-20.
[98] 贾继东, 侯金林, 尹有宽, 等. 替比夫定或拉米夫定抗乙型肝炎病毒的疗效预测探讨. 中华肝脏病杂志, 2007,15(5):342-345.
[99] Marcellin P, Heathcote EJ, Buti M, et al. Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B. N Engl J Med, 2008,359(23):2442-55.
[100] Heathcote EJ, Marcellin P, Buti M, et al. Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B. Gastroenterology, 2010.
[101] Yuen MF, Fong DY, Wong DK, et al. Hepatitis B virus DNA levels at week 4 of lamivudine treatment predict the 5-year ideal response. Hepatology, 2007,46(6):1695-703.
[102] Keeffe EB, Zeuzem S, Koff RS, et al. Report of an international workshop: Roadmap for management of patients receiving oral therapy for chronic hepatitis B. Clin Gastroenterol Hepatol, 2007,5(8):890-7.
[103] Chan HL, Tang JL, Tam W, et al. The efficacy of thymosin in the treatment of chronic hepatitis B virus infection: a meta-analysis. Aliment Pharmacol Ther, 2001,15(12):1899-905.
[104] Chien RN, Liaw YF, Chen TC, et al. Efficacy of thymosin alpha1 in patients with chronic hepatitis B: a randomized, controlled trial. Hepatology, 1998,27(5):1383-7.
[105] Hui CK, Cheung WW, Zhang HY, et al. Kinetics and risk of de novo hepatitis B infection in HBsAg-negative patients undergoing cytotoxic chemotherapy. Gastroenterology, 2006,131(1):59-68.
[106] 中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组, 等. 肝衰竭诊疗指南. 中华肝脏病杂志, 2006,14(9):643-646.
[107] Hung IF, Poon RT, Lai CL, et al. Recurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection. Am J Gastroenterol, 2008,103(7):1663-73.
[108] Koda M, Nagahara T, Matono T, et al. Nucleotide analogs for patients with HBV-related hepatocellular carcinoma increase the survival rate through improved liver function. Intern Med, 2009,48(1):11-7.
[109] Sokal EM, Kelly D, Wirth S, et al. The pharmacokinetics and safety of adefovir dipivoxil in children and adolescents with chronic hepatitis B virus infection. J Clin Pharmacol, 2008,48(4):512-7.
[110] Lok AS, McMahon BJ. Chronic hepatitis B: update of recommendations. Hepatology, 2004,39(3):857-61.