陈德喜，男，主任医师，擅长各类传染类疾病。

　1982.9-1987.7：包头医学院医学系本科。

　1990.9-1993.7： 包头医学院生化硕士研究生(1990-1991 在首都医科大学学习基础课)。

　1994.9-1997.7：北京医科大学生物化学与分子生物专业博士。

　1997.8-2000.11：博士后学习。美国匹兹堡大学医学院神经系脑缺血分子生物研究室做博士后。主要研究课题是： 一，寻找脑缺血诱导的神经保护性新基因。二，脑缺血后基因修复的分子机制。

　2000.12 -2002.8: 助理研究员(Assistant Scientist)俄勒冈州 波特兰市 DowS Neurobiology Labs。负责脑缺血耐受现象的分子生物学机制研究。

　2002.9-2006.8: 2002年9月：Research Assistant Professor。受聘于俄勒冈州立医科大学医学院肿瘤研究所，从事肿瘤凋亡调控的分子机制研究。

　2006.9-现在：首都医科大学附属北京佑安医院艾滋病研究室主任，教授和博士生导师。

在美国期间先后参与和协作主持了6个NIH基金：

　“Inducible DNA Repair in Cerebral Ischemia” R01 2R01NS036736-05 NIH/NINDS, Principal Investigator: Jun Chen, M.D., Ph.D.; Co-Investigator: Dexi Chen, Ph.D. 2000-2005

　“Mitochondrial DNA Damage and Repair in Ischemic Brain Injury” R01 1R01NS038560-01 NIH/NINDS, Principal Investigator: Jun Chen, M.D., Ph.D.; Co-Investigator: Dexi Chen, M.D., Ph.D. 1998-2003

　“Cell Excitation in Ischemic Brain Injury” RO1 NS24728-14 NIH/NINDS, Principal Investigator: Roger, P Simon, M.D., Ph.D.。2000-2005

　"Molecular Mechanisms in Ischemia” 1 PO1 NS35965-01 (Program Project Grant; RP SIMON PI).1997-2002

　“A Role of Acid-Sensing Ion Channels in Ischemia” R21 1R21NS042799-01 Exploratory/Developmental Grant Program. Agency: NIH/NINDS, Principal Investigator: Roger P simon, M.D., Ph.D.; 2001-2003

　“Mechanisms linking ASPP2 to the Rb/E2F1 and p53 pathway” Ro1CA104997-01. Lopez (PI), Co-Investigator, Dexi chen, M.D., Ph.D. 2004-2009。

　北京市科委1400万艾滋病重大课题(D0909003040591)参与者(2006-2009)

　Memberships in Professional Organization

　Society for Neuroscience 1998-2003

　American Association for Cancer Research 2003 – present

发表论文：

　1. Dexi Chen, Zhiyong Yu, Zhiyi Zhu, Lopez CD. E2F target to XRCC1and contribution to single strand broken repair in S phase. Will be Presented in AACR 97th annual meeting, 2006, April 1 – 5 Washington DC (Submitted to Cell death and differation)

　2. Dexi Chen , Zhiyi Zhu, Zhiyong Yu, Charles D. Lopez . An intact p53 pathway is required for efficient mitochondrial BER. Cancer Research. 2006,66(&):3485-3494.

　3. Zhiyi Zhu, Jason Ramos, Kerstin Kampa, Zhiyong Yu, Dexi chen, Charles Lopez. ASPP2 Apoptotic is Modulated by Proteasomal Degradation. J. Biol. Chem. 2005 288(41): 34473-88.

　4. Li Ning, Wu Hao, Sufang Yang, Dexi Chen#. Ischemic Preconditioning Induces the Expression of Base Excision Repair (BER) Enzymes- Indicating An Important Role for DNA Repair in Focal Ischemic Tolerance. ( In press J DNA Repair)

　5. Chen D, Padiernos E, Ding F, Lossos IS, Lopez CD. Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene.Cell Death Differ. 2005 Apr;12(4):358-68

6. Meller R, Minami M, Cameron J, Chen D, Lan J, HenshaLL D, SIMON R. CREB-mediated Bcl-2 protein expression following ischemic preconditioning. 2005 Feb;25(2):234-46.

　7. Dexi Chen, Manabu Minami, David C. Henshall; Roger P. Simon. Preconditioning Ischemia Enhances Base-Excision Repair Capability within Rat Brain Mitochondrial DNA. J Cereb Blood Flow Metab. 2003 Jan;23(1):88-98.

　8. Dexi Chen‡, Kunlin Jin*, Kenji Kawaguchi†, Masaki Nakayama†, Xiaoman Zhou‡, Zhigang Xiong‡, An Zhou‡, David A. Greenberg*, Steven H. Graham†, and Roger P. Simon‡. Ero1-L, an Ischemia-Inducible Gene from Rat Brain with Homology to Global Ischemia-Induced Gene 11 (Giig11), is Localized to Neuronal Dendrites by a Dispersed Identifier (ID)Element-Dependent Mechanism. J Neurochem. 2003 May;85(3):670-9

　9. Dexi Chen, Guodong Cao, Cristine O’Horo, Wei Pei and Jun Chen. DNA Base-Excision Repair Activity for Oxidative Lesions in Rat Brain Mitochondria: Marked Age-dependent Regulation. J Neurochem 2002 81 1273-1284.

　10. K. Jin1, X.O. Mao1, M.C. Eshoo1, G. del Rio1, R. Rao1 , D. Chen2, R.P. Simon2 and D.A. Greenberg.1cDNA Microarray Analysis of Changes in Gene Expression Induced by Neuronal Hypoxia In Vitro. Neurochem Res. 2002 Oct;27(10):1105-12.

　11. Xiangping Chu; J. Jefferson; M. Johnson; L. Root; X. Zhu.; Dexi Chen; R. Simon; Z. Xiong. PC12 cells contain a singtle population of functional protein-gated channels-homomultimeric asic1A. J Neuroph 2002, 87 2555-256.

　12. Martha B. Johnson, Manabu Minami, Dexi Chen, Roger P. Simon. Global ischemia induces expression of Asic2 in rat brain. J Cereb Blood Flow Metab. 2001, 21:734-740

　13. Li YY, Chen D, Watkins SC, Feldman AM..Mitochondrial Abnormalities in Tumor Necrosis Factor-alpha-Induced Heart Failure Are Associated With Impaired DNA Repair Activity. Circulation. 2001 Nov 13;104(20):2492-7

　14. Cao G, Minami M, Pei W, Yan C, Chen D, O'Horo C, Graham SH, Chen J. Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death.　J Cereb Blood Flow Metab. 2001 Apr;21(4):321-33.

　15. Chen D, Stetler RA, Cao GD, Pei W, Yin X-M, Chen J. Characterization of the rat DFF35/ICADs: the endogenous inhibitor of DNA fragmentation in neuronal apoptosis. J Biol Chem. 2000 Dec 8;275(49):38508-17.

　16. Chen D, Jing Lan, Wei Pei, Jun Chen. Detection of DNA Base-Excision repair activity for oxidative lesions in adult rat brain mitochondria. J Neurosci Res 2000. 61(2):225-236.

　17. Yan C, Chen J, Chen D, Minami M, Pei W, Yin XM, Simon RP. Overexpression of the cell death suppressor Bcl-w in ischemic brain: implications for a neuroprotective role via the mitochondrial pathway. J Cereb Blood Flow Metab 2000 Mar;20(3):620-30.

　18. Nagayama T, Lan J, Henshall DC, Chen D, O'Horo C, Simon RP